Pro-resolving mediators in OA: Homeostatic signals in the joint organ?
Concept
Inflammation is a key component of OA in a large number of patients and a clear therapeutic target. This project explores the impact of molecules produced in the joint that have anti-inflammatory properties.
Such molecules are used by the body to limit the impact of inflammation. Understanding their production and effects in patients with joint disease could help in better controlling the deleterious effects of inflammation on the tissues of the joint, in particular the cartilage and the bone.
Facts and Figures
R Lories
KU Leuven
rik.lories@uz.kuleuven.be
Meet the Team
University of Milano
University of Milano
UMC Leiden
University of Debrecen
Final Results
Inflammation is the hallmark feature of many rheumatic and musculoskeletal diseases. The importance of inflammation is a factor that contributes to the severity and symptoms of osteoarthritis which was traditionally considered as degenerative joint disease.
Final report
Publications
- Ioan-Facsinay A, Kloppenburg M. Bioactive lipids in osteoarthritis: risk or benefit? Curr Opin Rheumatol. 2018 Jan;30(1):108-113. doi:10.1097/BOR.0000000000000463. PubMed PMID: 29035931.
Read more - Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ. DOT1L safeguards cartilage homeostasis and protectsagainst osteoarthritis. Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889. PubMed PMID: 28627522; PubMed Central PMCID: PMC5481839.
Read more - Ioan-Facsinay A, Kloppenburg M. Osteoarthritis: Inflammation and fibrosis in adipose tissue of osteoarthritic joints. Nat Rev Rheumatol. 2017 Jun;13(6):325-326. doi: 10.1038/nrrheum.2017.53. Epub 2017 Apr 13. PubMed PMID: 28405000.
Read more - Jónasdóttir HS, Brouwers H, Kwekkeboom JC, van der Linden HM, Huizinga T, Kloppenburg M, Toes RE, Giera M, Ioan-Facsinay A. Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans. Osteoarthritis and Cartilage. 2017 Feb 8. pii: S1063-4584(17)30839-7. doi: 10.1016/j.joca.2017.01.018. [Epub ahead of print].
Read more - van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; EULAR Study group in OA. Translation of clinical problems in osteoarthritis into pathophysiological research goals. RMD Open. 2016 May 26;2(1):e000224. doi:10.1136/rmdopen-2015-000224. eCollection 2016. Erratum in: RMD Open. 2016 Oct7;2(2):e000224corr1. PubMed PMID: 27252894; PubMed Central PMCID: PMC4885448.
Read more - Brouwers H, von Hegedus J, Toes R, Kloppenburg M, Ioan-Facsinay A. Lipidmediators of inflammation in rheumatoid arthritis and osteoarthritis. Best Pract Res Clin Rheumatol. 2015 Dec;29(6):741-55. doi: 10.1016/j.berh.2016.02.003. Epub 2016 Mar 4. Review. PubMed PMID: 27107510.
Read more - van der Kraan PM, Berenbaum F, Blanco FJ, Cosimo de B, Lafeber F, Hauge E, Higginbottom A, Ioan-Facsinay A, Loughlin J, Meulenbelt I, Moilanen E, Pitsillidou I, Tsezou A, van Meurs J, Vincent T, Wittoek R, Lories R; Translation of clinical problems in osteoarthritis into pathophysiological research goals. RMD Open. 2016 May 26;2(1):e000224. doi: 10.1136/rmdopen-2015-000224. eCollection 2016.
Read more - de Jong AJ, Kloppenburg M, Toes RE, Ioan-Facsinay A. Fatty acids, lipid mediators, and T-cell function. Front Immunol. 2014 Oct 13;5:483. doi: 10.3389/fimmu.2014.00483. eCollection 2014. Review. PubMed PMID: 25352844; PubMed Central PMCID: PMC4195378.
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Patient Voice
For this laboratory project, based on novel technologies, patients have not been directly involved in the design of the experiments.
However, the development of novel strategies will clearly benefit the patients.
See final report for outcomes for the patients.