Inflammation is a key component of OA in a large number of patients and a clear therapeutic target. This project explores the impact of molecules produced in the joint that have anti-inflammatory properties.
Such molecules are used by the body to limit the impact of inflammation. Understanding their production and effects in patients with joint disease could help in better controlling the deleterious effects of inflammation on the tissues of the joint, in particular the cartilage and the bone.
Inflammation is the hallmark feature of many rheumatic and musculoskeletal diseases. The importance of inflammation is a factor that contributes to the severity and symptoms of osteoarthritis which was traditionally considered as degenerative joint disease.
For this laboratory project, based on novel technologies, patients have not been directly involved in the design of the experiments.
However, the development of novel strategies will clearly benefit the patients.
See final report for outcomes for the patients.