Objectives of the Project
Patients with SLE typically have circulating autoantibodies against DNA as a result of a humoral (auto-)immune response. The research project intends to comprehensively study the pathophysiology of the humoral autoimmune response in SLE patients. To do so, we intend to establish an in-depth understanding of the origins of SLE-specifi c autoantibodies in a unique
cohort of SLE patients who are treated with new biological therapies specifi cally targeted
at the formation of autoantibodies.