Objectives of the Project
Our study seeks to define the major clinical, environmental etc. factors that put someone at risk for lupus, especially the severe forms (e.g. kidney disease, neuropsychiatric lupus). These results will be complemented with the analysis of the genomic ‘make-up’ of individuals, which consists of several thousand genes (“transcriptome”) and is responsible for the disease.
First, patient registries of individuals with: autoantibodies but no disease, incomplete forms of lupus, and established lupus, will be reviewed to detect a first set of risk factors. Second, we will recruit healthy individuals with autoantibodies or first-degree relatives of patients with lupus.